2-Chloro-3-methoxypyridine-4-carbaldehyde → 1-(2-Chloro-3-methoxy-pyridin-4-yl)-3-phenyl-prop-2-yn-1-ol

반응식

[CH3:1][O:2][C:3]1[C:8]([CH:9]([OH:18])[C:10]#[C:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:7][CH:6]=C(OC)N=1.[Cl:21][C:22]1C(OC)=C(C=O)C=C[N:23]=1>>[Cl:21][C:22]1[C:3]([O:2][CH3:1])=[C:8]([CH:9]([OH:18])[C:10]#[C:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:7]=[CH:6][N:23]=1

참가 물질

반응물 2

HCID 597277402-Chloro-3-methoxypyridine-4-carbaldehyde

HCID 670678161-(2,6-Dimethoxy-pyridin-3-yl)-3-phenyl-prop-2-yn-1-ol

생성물 1

HCID 866710301-(2-Chloro-3-methoxy-pyridin-4-yl)-3-phenyl-prop-2-yn-1-ol수율 100%

실험 절차

Following the procedure used to prepare 1-(2,6-dimethoxy-pyridin-3-yl)-3-phenyl-prop-2-yn-1-ol, 2-chloro-3-methoxy-pyridine-4-carbaldehyde was reacted to give the title compound (1.60 g, 100%) as a colourless solid, LCMS (Method A): RT=4.14 min, [M+H]+=274/276.

후처리

customwas reacted

출처 및 근거

ORD 기록: ord-c11d342059f74501a2ad132532ca7d68
출처 데이터셋: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08546376B2

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