참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Naltrexone Base | HCID 21159611 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Naltrexone Hydrochloride | HCID 5485201 | — |
반응 단계
70 kg Naltrexone base is taken in 210 Lit DM water and pH was adjusted to ˜2.0 with Conc. HCl and heated to 70-75° C. to get clear solution, filtered to make particle free and slowly cooled to 2-5° C. in 6-8 hrs period, filtered and then dried. The base was generated from filtrate by treatment with sodium hydroxide and converted to HCl salt by repeating the above mentioned process. Yield: 59.8 kg
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08546572B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_10 |
|---|
| ORD ID | ord-255dff4051a1443da45aa8f55e091af9 |
|---|
| 출처 메모 | uspto-grants-2013_10 |
|---|
