Methanol → 5-Amino-2-(2-(methylsulfonyl)ethyl)isoquinolin-1(2H)-one

HRID 1037784노트

반응식

HRID 1037784 반응식
[CH3:1][S:2]([CH2:5][CH2:6][N:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[N+:17]([O-])=O)[C:8]1=[O:20])(=[O:4])=[O:3].CO>>[NH2:17][C:13]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:14]=1[CH:15]=[CH:16][N:7]([CH2:6][CH2:5][S:2]([CH3:1])(=[O:4])=[O:3])[C:8]2=[O:20]

참가 물질

3

반응물 2

HCID 887MethanolHCID 595798122-(2-(Methylsulfonyl)ethyl)-5-nitroisoquinolin-1(2H)-one

생성물 1

HCID 595796075-Amino-2-(2-(methylsulfonyl)ethyl)isoquinolin-1(2H)-one

실험 절차

Into a 250 ml round bottom flask was combined 2-(2-(methylsulfonyl)ethyl)-5-nitroisoquinolin-1(2H)-one (1.20 g, 0.00405 mol) Palladium/C (0.04 g, 0.0004 mol) and methanol (40 mL, 1 mol). The flask was evacuated and purged with hydrogen 3 times. The mixture was stirred at room temperature under hydrogen (1 atm) for three hours. The mixture was filtered over celite and the filtrate was reduced in vacuo. The mixture was purified by column chromatography using a Methanol:methylene chloride (0-10%) gradient. The combined pure fractions were reduced in vacuo to yield the title compound as an off white solid.

후처리

  1. customInto a 250 ml round bottom flask was combined
  2. customThe flask was evacuated
  3. custompurged with hydrogen 3 times
  4. filtrationThe mixture was filtered over celite
  5. customThe mixture was purified by column chromatography

출처 및 근거

ORD 기록
ord-441c443a234d4a5fb3258bfa1dfe05c5
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546579B2

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