Methanol → HCID 59579790, 화합물

HRID 1037786노트

반응식

HRID 1037786 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[CH3:16])[C:9]2=[O:14])([O-])=O.CO>[Pd]>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[CH3:16])[C:9]2=[O:14]

참가 물질

4

반응물 2

HCID 887MethanolHCID 595797305-nitro-2-(1-(pyridin-2-yl)ethyl)isoquinolin-1(2H)-one

생성물 1

HCID 59579790HCID 59579790, 화합물

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Into a round bottom flask was combined 5-nitro-2-(1-(pyridin-2-yl)ethyl)isoquinolin-1(2H)-one (0.85 g, 0.0029 mol), Palladium/C (0.05 g, 0.0005 mol) and methanol (200 mL, 5 mol). The reaction mixture was stirred under hydrogen balloon at room temperature for 40 mins. The mixture was filtered over celite, MeOH was removed and the solid was yield (0.54 mg). MS m/z=266.0 (M+1). 1H NMR (DMSO) δ 8.55 (d, J=4.8 Hz, 1 H), 7.77 (td, J=7.7, 1.8 Hz, 1 H); 7.44 (d, J=7.8 Hz, 1 H), 7.35-7.25 (m, 3 H), 7.17 (t, J=7.8 Hz, 1 H), 6.95-6.85 (m, 1 H), 6.78 (d, J=7.8 Hz, 1 H), 6.28 (q, J=7.2 Hz, 1 H), 5.66 (s, 2 H), 1.75 (d, J=7.2 Hz, 3 H).

후처리

  1. customInto a round bottom flask was combined
  2. filtrationThe mixture was filtered over celite, MeOH
  3. customwas removed
  4. customthe solid was yield (0.54 mg)

출처 및 근거

ORD 기록
ord-315a62beed394b28a6a13ca24c75e09b
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546579B2

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