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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Triethylamine → 1-{2-Oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide

HRID 1037986
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HRID 1037986 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH2:17])[CH:15]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.[O:18]=[C:19]([N:29]1[CH2:34][CH2:33][N:32]([C:35]2[CH:40]=[CH:39][C:38]([C:41]3[N:46]=[CH:45][CH:44]=[CH:43][N:42]=3)=[CH:37][CH:36]=2)[CH2:31][CH2:30]1)[CH2:20][N:21]1[CH2:25][CH2:24][CH:23]([C:26](O)=[O:27])[CH2:22]1.C(N(CC)CC)C>CN(C=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH:17][C:26]([CH:23]4[CH2:24][CH2:25][N:21]([CH2:20][C:19](=[O:18])[N:29]5[CH2:30][CH2:31][N:32]([C:35]6[CH:40]=[CH:39][C:38]([C:41]7[N:42]=[CH:43][CH:44]=[CH:45][N:46]=7)=[CH:37][CH:36]=6)[CH2:33][CH2:34]5)[CH2:22]4)=[O:27])[CH:15]=3)[NH:10][N:9]=2)=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 224802843-(4-fluorophenyl)-1H-indazol-5-amineHCID 674194121-{2-Oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid2회

생성물 1

HCID 674186161-{2-Oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide수율 24.3%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

3-(4-Fluoro-phenyl)-1H-indazol-5-ylamine (0.11 gm, 0.5 mmol) and 1-{2-Oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid (compound 12 from Step 9, 0.125 gm, 0.25 mmol) were dissolved in 4 ml of DMF. O-(7-azabenzotriazol-1-yl-)-N,N,N,N-tetramethyluronium hexafluorophosphate (HATU) (0.24 gm, 0.63 mmol) and triethylamine (0.1 ml, 0.76 mmol) were added to the reaction mixture and the mixture stirred for 18 hrs. The reaction mixture was added to bring and extracted with dichloromethane. After drying over magnesium sulfate and filtered, the mixture was evaporated and chromatographed to obtain 36.7 mg of title product.

후처리

  1. additionThe reaction mixture was added
  2. extractionextracted with dichloromethane
  3. dry with materialAfter drying over magnesium sulfate
  4. filtrationfiltered
  5. customthe mixture was evaporated
  6. customchromatographed

출처 및 근거

ORD 기록
ord-28a69d1d9e274c4eb35d0d6333e45324
출처 데이터셋
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08546404B2

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