Potassium Nitrate → 5-nitro-1H-indazole-3-carboxylic Acid

HRID 1038003

반응식

HRID 1038003 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=[O:11])=[N:2]1.[N+:13]([O-])([O-:15])=[O:14].[K+]>S(=O)(=O)(O)O>[N+:13]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[NH:1][N:2]=[C:3]2[C:10]([OH:12])=[O:11])([O-:15])=[O:14]

참가 물질

4

반응물 2

HCID 24434Potassium NitrateHCID 78250Indazole-3-carboxylic acid2회

생성물 1

HCID 71446525-nitro-1H-indazole-3-carboxylic Acid수율 77.8%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

To a suspension of indazole-3-carboxylic acid (compound 53, 3.0 g, 18 mmol) in 18 mL of concentrated sulfuric acid at 0 C was added potassium nitrate (2.0 g, 18 mmol). The reaction was stirred overnight at room temperature, poured into 150 mL of ice and extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried and concentrated to give compound 54 (2.9 g) as the major isomer.

후처리

  1. extractionextracted three times with ethyl acetate
  2. washThe combined organic layer was washed with brine
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fb4db22b2cdb4767bbd69603836df4b1
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546404B2

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