Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1038033생성일: 2026년 10월 27일
Cesium fluoride → 4-(5-Pyrimidin-2-yl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/1038033
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium fluoride | HCID 25953 | — |
| 반응물 | 2-(Tributylstannyl)pyrimidine | HCID 2763251 | — |
| 반응물 | Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)piperazine-1-carboxylate | HCID 34180719 | — |
| 촉매 | Di-t-butylphosphine palladium | HCID 86614436 | — |
| 생성물 | 4-(5-Pyrimidin-2-yl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 59511356 | — |
반응 단계
A round bottom flask containing 4-(5-bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (100 mg, 0.29 mmol), 2-tributylstannanyl-pyrimidine (130 mg, 0.36 mmol), cesium fluoride (85 mg, 0.56 mmol) and palladium di-tert-butylphosphine was degassed three times with Ar. Dioxane was added and the formed reaction mixture was stirred at 90° C. overnight under Ar. Then the reaction mixture was filter through celite and the solvent was removed under vacuum and crude product was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08546404B2 |
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| 출처 데이터셋 | uspto-grants-2013_10 |
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| ORD ID | ord-0fa3a91681314b309e1665df91b7da55 |
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| 출처 메모 | uspto-grants-2013_10 |
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