Bromine → 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine

HRID 1038121노트

반응식

HRID 1038121 반응식
[N:1]1([C:6]2[N:11]=[CH:10][CH:9]=[CH:8][N:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[Br:12]Br>C(O)(=O)C>[Br:12][C:4]1[CH:3]=[N:2][N:1]([C:6]2[N:7]=[CH:8][CH:9]=[CH:10][N:11]=2)[CH:5]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 111707712-(1H-Pyrazol-1-yl)pyrimidine

생성물 1

HCID 457897012-(4-Bromo-1H-pyrazol-1-yl)pyrimidine수율 85%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

To a solution of 2-pyrazol-1-yl-pyrimidine (0.55 g, 3.7 mmol) in acetic acid (5 mL) was added bromine (1.2 g, 7.5 mmol) in acetic acid (3 mL) dropwisely. After addition, the reaction mixture was stirred at room temperature overnight. After removed the acetic acid, the crude product was purified using column chromatography (2% methanol in dichloromethane) to give 0.7 g of pure product in 85% yield. MS (ESMS, M+H 225).

후처리

  1. additionAfter addition
  2. customAfter removed the acetic acid
  3. customthe crude product was purified

출처 및 근거

ORD 기록
ord-19f31f338b3a44819c22eb0230e11faa
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546404B2

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