Water → (2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

HRID 1038346

반응식

HRID 1038346 반응식
[CH3:1][O-:2].[Na+].[Br:4][C:5]1[CH:10]=[C:9](F)[CH:8]=[CH:7][C:6]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=1)=[O:13].O>CN(C=O)C>[Br:4][C:5]1[CH:10]=[C:9]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=1)=[O:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 10942334Sodium Methoxide2회HCID 43338337(2-Bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone

생성물 1

HCID 58385812(2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Sodium methoxide (10.5 g) is added portionwise to (2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone (43.0 g) dissolved in DMF (200 mL). The solution is stirred overnight, before another portion of sodium methoxide (5.5 g) is added. After another 3 h of stirring, water is added and the resulting mixture is extracted with ethyl acetate. The organic phase is dried (sodium sulphate), the solvent is removed and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1).

후처리

  1. additionis added
  2. extractionthe resulting mixture is extracted with ethyl acetate
  3. dry with materialThe organic phase is dried (sodium sulphate)
  4. customthe solvent is removed
  5. customthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1)

출처 및 근거

ORD 기록
ord-b354e4188c2e4cc2a8d1df8d6c944858
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08551957B2

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