Dimethylformamide → 1-Bromo-2-(chloromethyl)-4-iodobenzene

HRID 1038349노트

반응식

HRID 1038349 반응식
S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:11]=[CH:10][C:9]([I:12])=[CH:8][C:7]=1[CH2:13]O.CN(C=O)C>ClCCl>[Br:5][C:6]1[CH:11]=[CH:10][C:9]([I:12])=[CH:8][C:7]=1[CH2:13][Cl:3]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 53424372(2-Bromo-5-iodophenyl)methanol

생성물 1

HCID 593463281-Bromo-2-(chloromethyl)-4-iodobenzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thionyl chloride (13 mL) is added to a suspension of 4-bromo-3-hydroxymethyl-1-iodo-benzene (47.0 g) in dichloromethane (100 mL) containing DMF (0.1 mL). The mixture is stirred at ambient temperature for 3 h. Then, the solvent and the excess reagent is removed under reduced pressure. The residue is triturated with methanol and dried.

후처리

  1. customThen, the solvent and the excess reagent is removed under reduced pressure
  2. customThe residue is triturated with methanol
  3. customdried

출처 및 근거

ORD 기록
ord-a212c4325e9043fb8a7a41eaedec2983
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08551957B2

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