Benzenesulfinic acid, sodium salt → 5-(1,3-Dioxolan-2-yl)-3-(phenylsulfonyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indazole

HRID 1038387노트

반응식

HRID 1038387 반응식
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:22])([CH3:21])[CH3:20])[N:10]=[C:9]2I.[C:24]1([S:30]([O-:32])=[O:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[Na+]>>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:22])([CH3:21])[CH3:20])[N:10]=[C:9]2[S:30]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:32])=[O:31]

참가 물질

3

반응물 2

HCID 2723840Benzenesulfinic acid, sodium saltHCID 584076045-(1,3-Dioxolan-2-yl)-3-iodo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indazole

생성물 1

HCID 584075995-(1,3-Dioxolan-2-yl)-3-(phenylsulfonyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indazole

실험 절차

The title compound was prepared following the procedure described for Example 9A using 150 mg (0.336 mmol) 5-(1,3-dioxolan-2-yl)-3-iodo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indazole (Example 6A) and 164 mg (1.01 mmol) sodium benzenesulfinate. After cooling, the reaction mixture was filtered, and the filtrate was purified by preparative RP-HPLC (acetonitrile/water+0.05% TFA gradient) to give 55 mg of a product mixture containing the title compound. This mixture was used in the next step without further purification.

후처리

  1. temperatureAfter cooling
  2. filtrationthe reaction mixture was filtered
  3. customthe filtrate was purified by preparative RP-HPLC (acetonitrile/water+0.05% TFA gradient)

출처 및 근거

ORD 기록
ord-b55af68931114250a884a301c3b9a3a7
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08551989B2

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