Potassium Carbonate → 2-(4-{5-[1,1,1,3,3,3-Hexafluoro-2-(4-methoxybenzyloxy)propan-2-yl]-4-propylpyridin-2-yl}piperazin-1-yl)ethanol

HRID 1038514노트

반응식

HRID 1038514 반응식
C([O:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[C:17]([CH2:19][CH2:20][CH3:21])[C:16]([C:22]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=3)([C:27]([F:30])([F:29])[F:28])[C:23]([F:26])([F:25])[F:24])=[CH:15][N:14]=2)[CH2:9][CH2:8]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[F:25][C:23]([F:24])([F:26])[C:22]([C:16]1[C:17]([CH2:19][CH2:20][CH3:21])=[CH:18][C:13]([N:10]2[CH2:11][CH2:12][N:7]([CH2:6][CH2:5][OH:4])[CH2:8][CH2:9]2)=[N:14][CH:15]=1)([O:31][CH2:32][C:33]1[CH:34]=[CH:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=1)[C:27]([F:30])([F:29])[F:28]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 866471792-(4-{5-[1,1,1,3,3,3-Hexafluoro-2-(4-methoxybenzyloxy)propan-2-yl]-4-propylpyridin-2-yl}piperazin-1-yl)ethyl acetate

생성물 1

HCID 866471802-(4-{5-[1,1,1,3,3,3-Hexafluoro-2-(4-methoxybenzyloxy)propan-2-yl]-4-propylpyridin-2-yl}piperazin-1-yl)ethanol수율 47%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-(4-{5-[1,1,1,3,3,3-Hexafluoro-2-(4-methoxybenzyloxy)propan-2-yl]-4-propylpyridin-2-yl}piperazin-1-yl)ethyl acetate (479 mg) was dissolved in methanol (2.3 mL), added potassium carbonate (127 mg, 0.722 mmol), and the mixture was stirred at room temperature for 0.5 hours. The reaction solution was concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (chloroform/methanol). The title compound (117 mg (yield 47%)) was obtained as a yellow oil.

후처리

  1. concentrationThe reaction solution was concentrated in vacuo
  2. customThe obtained residue was purified by silica-gel column chromatography (chloroform/methanol)

출처 및 근거

ORD 기록
ord-05a5d8d831ed420085abd5451819a7d8
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08551985B2

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