1,3-Dichloro-2-isocyanatobenzene → 1-(2,6-Dichloro-phenyl)-3-[6-(4-fluoro-phenylamino)-pyrimidin-4-yl]-urea

HRID 1038689노트

반응식

HRID 1038689 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[C:13]([NH2:15])[N:12]=[CH:11][N:10]=2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:18]=1[N:24]=[C:25]=[O:26]>O1CCOCC1>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:18]=1[NH:24][C:25]([NH:15][C:13]1[CH:14]=[C:9]([NH:8][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[N:10]=[CH:11][N:12]=1)=[O:26]

참가 물질

4

반응물 2

HCID 6045371,3-Dichloro-2-isocyanatobenzeneHCID 66669888N-(4-Fluoro-phenyl)-pyrimidine-4,6-diamine

생성물 1

HCID 577103381-(2,6-Dichloro-phenyl)-3-[6-(4-fluoro-phenylamino)-pyrimidin-4-yl]-urea

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
80 °C

실험 절차

A suspension of N-(4-fluoro-phenyl)-pyrimidine-4,6-diamine (408.4 mg, 2 mmol), 2,6-dichlorophenyl isocyanate (413.6 mg, 2.2 mmol) in dry dioxane (5 mL) is shaken for 14 h at 80° C. After cooling to 5° C. the suspension is filtered, the residue washed with half-saturated K2CO3 solution, H2O and acetone and dried in vacuo.

후처리

  1. temperatureAfter cooling to 5° C. the suspension
  2. filtrationis filtered
  3. washthe residue washed with half-saturated K2CO3 solution, H2O and acetone
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-a08985a5ca8044b6a02b7f970436d2c3
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552002B2

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