1,3-Dichloro-2-isocyanatobenzene → 3-(2,6-Dichloro-phenyl)-1-[6-(2,4-difluoro-phenylamino)-pyrimidin-4-yl]-1-methyl-urea

HRID 1038694

반응식

HRID 1038694 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:15]=[C:14]([NH:16][CH3:17])[N:13]=[CH:12][N:11]=1.[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:20]=1[N:26]=[C:27]=[O:28]>>[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:20]=1[NH:26][C:27](=[O:28])[N:16]([C:14]1[CH:15]=[C:10]([NH:9][C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])[N:11]=[CH:12][N:13]=1)[CH3:17]

참가 물질

3

반응물 2

HCID 6045371,3-Dichloro-2-isocyanatobenzeneHCID 66669984HCID 66669984, 화합물

생성물 1

HCID 577102263-(2,6-Dichloro-phenyl)-1-[6-(2,4-difluoro-phenylamino)-pyrimidin-4-yl]-1-methyl-urea

실험 절차

The title compound is prepared analogously as described in Example 105B from N-(2,4-difluoro-phenyl)-N′-methyl-pyrimidine-4,6-diamine and 2,6-dichlorophenyl isocyanate.

출처 및 근거

ORD 기록
ord-952c271816984802a11722bf6cea9565
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552002B2

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