Benzene, 1-chloro-3-isocyanato- → 3-(3-Chloro-Phenyl)-1-[6-(4-fluoro-phenylamino)-pyrimidin-4-yl]-1-methyl-urea

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[C:13]([NH:15][CH3:16])[N:12]=[CH:11][N:10]=2)=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:19]=[C:20]([N:24]=[C:25]=[O:26])[CH:21]=[CH:22][CH:23]=1>>[Cl:17][C:18]1[CH:19]=[C:20]([NH:24][C:25](=[O:26])[N:15]([C:13]2[CH:14]=[C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[N:10]=[CH:11][N:12]=2)[CH3:16])[CH:21]=[CH:22][CH:23]=1

참가 물질

반응물 2

HCID 17968Benzene, 1-chloro-3-isocyanato-

HCID 66669841N4-(4-fluorophenyl)-N6-methylpyrimidine-4,6-diamine

생성물 1

HCID 577104253-(3-Chloro-Phenyl)-1-[6-(4-fluoro-phenylamino)-pyrimidin-4-yl]-1-methyl-urea

실험 절차

The title compound is prepared analogously as described in Example 121 from N-(4-fluoro-phenyl)-N′-methyl-pyrimidine-4,6-diamine and 3-chlorophenyl isocyanate.

출처 및 근거

ORD 기록: ord-a29a2c15a000433aae1f3edd94090d0a
출처 데이터셋: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08552002B2

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