Chlorophenyl isocyanate → 1-(2-Chloro-phenyl)-3-(6-chloro-pyrimidin-4-yl)-urea

HRID 1038701노트

반응식

HRID 1038701 반응식
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N:16]=[C:17]=[O:18]>C1COCC1>[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][C:17]([NH:8][C:4]1[CH:3]=[C:2]([Cl:1])[N:7]=[CH:6][N:5]=1)=[O:18]

참가 물질

4

반응물 2

HCID 76833Chlorophenyl isocyanate2회HCID 2380124-Amino-6-chloropyrimidine

생성물 1

HCID 860869821-(2-Chloro-phenyl)-3-(6-chloro-pyrimidin-4-yl)-urea수율 174.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 6-chloro-pyrimidin-4-ylamine (997 mg, 7.7 mmol) and 2-chlorophenyl isocyanate (0.46 mL, 3.85 mmol) in THF (20 mL) is refluxed for 4 h. A further amount of 2-chlorophenyl isocyanate (0.46 mL, 3.85 mmol) is added and the reaction mixture is refluxed for 28 h. The reaction mixture is cooled to RT, the precipitate is filtered to afford the title compound (1.9 g, 86%).

후처리

  1. temperaturethe reaction mixture is refluxed for 28 h
  2. filtrationthe precipitate is filtered

출처 및 근거

ORD 기록
ord-783f840a770941c9856e0b181da665f4
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552002B2

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