Triethyl orthoacetate → 3-(3,4-dichlorophenyl)-2-methylquinazolin-4-one
반응식
[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([Cl:14])[CH:8]=1)=[O:5].[CH2:19](OC(OCC)(OCC)C)[CH3:20]>O>[CH3:19][C:20]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([Cl:14])[CH:8]=2)[C:4](=[O:5])[C:3]2[C:2](=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:1]=1참가 물질
4
실험 절차
A mixture of 62 (2.8 g, 0.009 mol) and 1,1,1-triethoxy-ethane (5.2 mL, 0.028 mol) were heated for 5 hours. The reaction mixture was poured into water, filtered, washed with water yielding compound 63 (55%). After recrystallization from EtOH, the material was used in next step without further purification.
후처리
- temperaturewere heated for 5 hours
- filtrationfiltered
- washwashed with water yielding compound 63 (55%)
- customAfter recrystallization from EtOH
- customthe material was used in next step without further purification
출처 및 근거
- ORD 기록
- ord-077354279ce64dbb897bd382a0150834
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08552009B2
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