Methanol → 4-Benzo[4,5]furo[3,2-d]pyrimidin-4-yl-piperazine-1-carbothioic acid [4-(Pyrimidin-2-ylsulfamoyl)-phenyl]-amide

참여 물질

역할	이름	HCID	투입량
반응물	Methanol	HCID 887	—
반응물	Pyridine	HCID 1049	—
반응물	4-(Piperazin-1-yl)benzofuro[3,2-d]pyrimidine	HCID 2368542	—
반응물	N-Pyrimidin-2-yl-4-thioformylamino-benzenesulfonamide chloride	HCID 86601004	—
용매	Dichloromethane	HCID 6344	—
생성물	4-Benzo[4,5]furo[3,2-d]pyrimidin-4-yl-piperazine-1-carbothioic acid [4-(Pyrimidin-2-ylsulfamoyl)-phenyl]-amide	HCID 11753137	—

반응 단계

To a solution of 4-piperazinobenzofurano[3,2-d]pyrimidine (200 mg, 0.79 mmol) and pyridine (0.5 mL, 7.9 mmol) in dichloromethane (20 mL) was added a solution of product 1d in dichloromethane (20 mL) and this was stirred overnight. Methanol was added to quench excess thiophosgene; and the residue after removal of solvent was purified by silica gel column chromatography eluting with 5% methanol/dichloromethane and further recrystallized from dichloromethane/hexane to give 150 mg (37%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08552018B2
출처 데이터셋	uspto-grants-2013_10
ORD ID	ord-c1bba94319e7483a8511f98f0c4046e8
출처 메모	uspto-grants-2013_10