Water → 5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

HRID 1039061

반응식

HRID 1039061 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

참가 물질

6

반응물 4

HCID 962WaterHCID 92571H-1,2,4-TriazoleHCID 10796Cesium carbonateHCID 952642-Fluoro-5-nitropyridine

생성물 1

HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-fluoro-5-nitropyridine (0.5 g, 3.38 mmol), 1,2,4-triazole (0.22 g, 3.22 mmol) were added in DMF (6.4 mL), then cesium carbonate (3.14 g, 9.65 mmol) was added. The reaction was run at room temperature for 30 minutes. Water (50 mL) was added and product fell out of the solution. The solution was filtered and the solid was rinsed with ethyl acetate/water (1:1, 20 mL×2), hot hexane (20 mL) to give the title compound as a white solid.

후처리

  1. filtrationThe solution was filtered
  2. washthe solid was rinsed with ethyl acetate/water (1:1, 20 mL×2), hot hexane (20 mL)

출처 및 근거

ORD 기록
ord-f57ebb80bb79433bb24a6b091ca610d5
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552022B2

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