1-Fluoro-4-(methylsulphonyl)benzene → HCID 67778059, 화합물

HRID 1039106노트

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HRID 1039106 반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([CH:14]3[CH2:16][CH:15]3[CH2:17][CH2:18][NH2:19])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.F[C:21]1[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=1.C1CCN2C(=NCCC2)CC1>CN1C(=O)CCC1.O>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([CH:14]3[CH2:16][CH:15]3[CH2:17][CH2:18][NH:19][C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1

참가 물질

6

반응물 3

HCID 679941-Fluoro-4-(methylsulphonyl)benzeneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 669270622-{2-[1-(5-Chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanamine

생성물 1

HCID 67778059HCID 67778059, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 13387N-methyl-2-pyrrolidone용매

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온도
110 °C

실험 절차

2-{2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanamine from step 3 of this example (50 mg, 0.178 mmol) was in 0.594 mL NMP. 1-fluoro-4-(methylsulfonyl)benzene (37.2 mg, 0.2141 mol) and DBU (0.040 mL, 0.267 mmol) were sequentially added. The reaction mixture was stirred at 110° C. overnight before cooled back to room temperature. The reaction mixture was diluted with water and aqueous phase was further extracted with ethyl acetate for 3 times. The combined organic layers were washed with water and brine, then dried over Na2SO4 and concentrated. The residue was purified by column chromatography using gradient elution (0 to 65% ethyl acetate in hexane) to give the titled compound. LRMS calc: 434.9; obs: 435 (M+1).

후처리

  1. temperaturebefore cooled back to room temperature
  2. extractionwas further extracted with ethyl acetate for 3 times
  3. washThe combined organic layers were washed with water and brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated
  6. customThe residue was purified by column chromatography
  7. washelution (0 to 65% ethyl acetate in hexane)

출처 및 근거

ORD 기록
ord-0deac29ef3874f8fba2af49edc399877
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552022B2

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