Methyl 2-isothiocyanatoacetate → Methyl 2-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]-ethylidene}-hydrazinocarbonothioyl)amino]acetate

참여 물질

역할	이름	HCID	투입량
반응물	Methyl 2-isothiocyanatoacetate	HCID 140795	—
반응물	Methanol--water (1/1)	HCID 22242641	—
반응물	2-(3,4-Dichlorophenyl)-4-(1-hydrazinylideneethyl)thiophene-3-ol	HCID 71405258	—
용매	Dimethylformamide	HCID 6228	—
생성물	Methyl 2-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]-ethylidene}-hydrazinocarbonothioyl)amino]acetate	HCID 72989195	0.72%

반응 조건

온도	50 °C

반응 단계

A solution of 2-(3,4-dichlorophenyl)-4-(1-hydrazonoethyl)thiophen-3-ol (30 mg, 0.10 mmol) prepared in Reference Synthetic Example 1 and methyl 2-isothiocyanatoacetate (20 mg, 0.15 mmol) in dimethyl formamide (300 μL) was stirred at room temperature, 40° C. and 50° C. for 2 hours, respectively. After addition of methanol-water, the solution was stirred at room temperature for 0.5 hour, and the resulting crystals were collected by filtration as the desired product (yield 0.72%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08552031B2
출처 데이터셋	uspto-grants-2013_10
ORD ID	ord-174b428f226c401d8f06bcc59d88b3b8
출처 메모	uspto-grants-2013_10