Water → 4-[2-(5-amino-4-[4-cyclopropyl-7-methoxynaphthalen-1-yl]-4H-1,2,4-triazol-3-ylthio)acetamido]-3-chlorobenzoic acid

HRID 1039386

반응식

HRID 1039386 반응식
[NH2:1][C:2]1[N:3]([C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=3)[C:25]([CH3:34])=[CH:24][CH:23]=2)[C:4]([S:7][CH2:8][C:9]([NH:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[Cl:21])=[O:10])=[N:5][N:6]=1.BrC1N(C2C3C(=CC=C(OC)C=3)C(C)=CC=2)C(S[CH2:42][C:43](NC2C=CC(C(O)=O)=CC=2Cl)=O)=NN=1.O>CN(C=O)C>[NH2:1][C:2]1[N:3]([C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=3)[C:25]([CH:34]3[CH2:43][CH2:42]3)=[CH:24][CH:23]=2)[C:4]([S:7][CH2:8][C:9]([NH:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[Cl:21])=[O:10])=[N:5][N:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 160586974-(2-(5-bromo-4-(7-methoxy-4-methylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetamido)-3-chlorobenzoic acidHCID 598131144-(2-(5-amino-4-(7-methoxy-4-methylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetamido)-3-chlorobenzoic acid

생성물 1

HCID 598131054-[2-(5-amino-4-[4-cyclopropyl-7-methoxynaphthalen-1-yl]-4H-1,2,4-triazol-3-ylthio)acetamido]-3-chlorobenzoic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
50 °C

실험 절차

Compound 10 (100 mg, 0.32 mmol) and 3-chloro-4-(2-chloroacetamido)benzoic acid (11) (79 mg, 0.32 mmol) were dissolved in DMF (2 mL) and the mixture was stirred at 50° C. for 18 hours. Water was then added to the mixture and the precipitate formed collected to give the crude 4-[2-(5-amino-4-[4-cyclopropyl-7-methoxynaphthalen-1-yl]-4H-1,2,4-triazol-3-ylthio)acetamido]-3-chlorobenzoic acid (12) which was used in next step without further purification.

후처리

  1. customthe precipitate formed
  2. customcollected

출처 및 근거

ORD 기록
ord-cb3e2801c85d41659708a0bee0a13ce3
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552043B2

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