5-Hydroxypyridine-2-carboxylic acid → N-((R)-5-Bromoindan-2-yl)-5-hydroxypyridine-2-carboxamide

반응식

[OH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[Br:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][C@@H:16]([NH2:21])[CH2:15]2>>[Br:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][C@@H:16]([NH:21][C:8]([C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][N:6]=1)=[O:10])[CH2:15]2

참가 물질

반응물 2

HCID 2687405-Hydroxypyridine-2-carboxylic acid

HCID 112758701H-Inden-2-amine, 5-bromo-2,3-dihydro-, (2R)-

생성물 1

HCID 66679915N-((R)-5-Bromoindan-2-yl)-5-hydroxypyridine-2-carboxamide

실험 절차

According to method C, 5-hydroxypyridine-2-carboxylic acid was reacted with (R)-5-bromo-indan-2-ylamine. This afforded the product with the molecular weight of 333.19 (C15H13BrN2O2); MS (ESI); 333 (M+H+).

후처리

customThis afforded the product with the molecular weight of 333.19 (C15H13BrN2O2)

출처 및 근거

ORD 기록: ord-c518c434b15f46268b2410ee9a9d0637
출처 데이터셋: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08552199B2

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