Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 5-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine fumarate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Fumaric Acid | HCID 444972 | — |
| 반응물 | 5-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine | HCID 19694295 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine fumarate | HCID 19694294 | 70% |
반응 단계
The above described pyridine derivative was converted into invention compound of Formula I by the addition of one equivalent of fumaric acid to a methanol (15 mL) solution of the free amine at 25° C. After 30 minutes the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether resulted in the formation of 5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate (70%) as a colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723477 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-78d0ff9eaef04c19a3803165f28b1df6 |
| 출처 메모 | uspto-grants-1998_03 |