Dichloromethane → 3-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol hydrochloride

HRID 1040302노트

반응식

HRID 1040302 반응식
[CH3:1][N:2]([CH3:16])[CH2:3][CH:4]([CH3:15])[CH:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7].[Cl:17]CCl>Cl.C(OC(C)C)(C)C>[ClH:17].[CH3:16][N:2]([CH3:1])[CH2:3][CH:4]([CH3:15])[CH:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7]

참가 물질

4

반응물 2

HCID 6344DichloromethaneHCID 64330913-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol

생성물 1

HCID 231069343-(1-(Dimethylamino)-2-methylpentan-3-yl)phenol hydrochloride

시약·촉매·용매 1

HCID 21510344Isopropyl ether hydrochloride용매

실험 절차

To stirred solution of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (4 g, 0.02 mol) in dichloromethane (20 ml), isopropyl ether hydrochloride (6 ml) was added at ambient temperature and stirred for 30 minutes. Solvents were distilled off from the reaction mixture. To the residue isopropyl ether (8 ml) was added and stirred for 15 minutes. Solvent was distilled off from the mixture to give 4.3 g of the title compound.

후처리

  1. additionwas added at ambient temperature
  2. distillationSolvents were distilled off from the reaction mixture
  3. additionTo the residue isopropyl ether (8 ml) was added
  4. stirringstirred for 15 minutes
  5. distillationSolvent was distilled off from the mixture

출처 및 근거

ORD 기록
ord-d3d93c13df264a87a63513b0942b1daf
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552219B2

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