Methanol → Methyl (1S,3R)-3-aminocyclopentane-1-carboxylate
반응식
[NH2:1][C@@H:2]1[CH2:6][CH2:5][C@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1.S(Cl)(Cl)=O.[CH3:14]O>>[CH3:14][O:8][C:7]([C@H:4]1[CH2:5][CH2:6][C@@H:2]([NH2:1])[CH2:3]1)=[O:9]참가 물질
4
실험 절차
To a solution of (1S,3R)-3-aminocyclopentanecarboxylic acid (1.0 g, 7.4 mmol) in dry MeOH (10 mL) under N2 at 0° C. was added thionyl chloride (2.7 mL, 36.8 mmol) dropwise. The reaction mixture was slowly warmed to room temperature and stirred overnight. The reaction was concentrated in vacuo. The resultant residue was washed with anhydrous diethyl ether (3×30 mL) and dried under high vacuum to afford 1.87 g of (1S,3R)-3-amino-cyclopentanecarboxylic acid methyl ester as the HCl salt that was used without further purification.
후처리
- concentrationThe reaction was concentrated in vacuo
- washThe resultant residue was washed with anhydrous diethyl ether (3×30 mL)
- customdried under high vacuum
출처 및 근거
- ORD 기록
- ord-b50be1066891416fbadabdbaba419cc6
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08552205B2
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