HCID 178521699, 화합물 → HCID 178507185, 화합물
반응식
C(OC(=O)[NH:10][C:11]1([C:14]2[NH:18][CH:17]=[N:16][N:15]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[N:16]1[N:15]=[C:14]([C:11]2([NH2:10])[CH2:13][CH2:12]2)[NH:18][CH:17]=1참가 물질
4
실험 절차
To a solution of [1-(4H-[1,2,4]triazol-3-yl)-cyclopropyl]-carbamic acid benzyl ester (60 mg, 0.23 mmol) in MeOH (5 mL) was added 10% Pd/C (60 mg). The reaction mixture was stirred under H2 atmosphere (balloon) for 1.5 h. The reaction mixture was filtered through diatomaceous earth. The solvent was concentrated in vacuo and dried under high vacuum to afford 28 mg of the title compound, m/z 125.5 [M+1]+.
후처리
- filtrationThe reaction mixture was filtered through diatomaceous earth
- concentrationThe solvent was concentrated in vacuo
- customdried under high vacuum
출처 및 근거
- ORD 기록
- ord-b1cbcd54f9224bd88a8376b29afa1e1f
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08552205B2
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