Trifluoroacetic acid → (2S,3R)-2-amino-3-tert-butoxy-N-(1-pyrimidin-2-yl-cyclopropyl)-butyramide trifluoro-acetic acid

HRID 1040500노트

반응식

HRID 1040500 반응식
C(OC(=O)[NH:7][C@H:8]([C:16](=[O:27])[NH:17][C:18]1([C:21]2[N:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[CH2:20][CH2:19]1)[C@H:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH3:10])(C)(C)C.[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30]>C(Cl)Cl>[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[NH2:7][C@@H:8]([C@H:9]([O:11][C:12]([CH3:13])([CH3:15])[CH3:14])[CH3:10])[C:16]([NH:17][C:18]1([C:21]2[N:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[CH2:19][CH2:20]1)=[O:27]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67390977[(1S,2R)-2-tert-butoxy-1-(1-pyrimidin-2-yl-cyclopropylcarbamoyl)-propyl]-carbamic acid tert-butyl ester

생성물 1

HCID 67389830(2S,3R)-2-amino-3-tert-butoxy-N-(1-pyrimidin-2-yl-cyclopropyl)-butyramide trifluoro-acetic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

[(1S,2R)-2-tert-butoxy-1-(1-pyrimidin-2-yl-cyclopropylcarbamoyl)-propyl]-carbamic acid tert-butyl ester (0.17 g, 0.45 mmol) was dissolved in DCM (1 mL) and to this was added TFA (0.2 mL). The reaction was allowed to stir at RT for 24 h. The solvent was removed under reduced pressure and the residue triturated with Et2O to give (2S,3R)-2-amino-3-tert-butoxy-N-(1-pyrimidin-2-yl-cyclopropyl)-butyramide trifluoro-acetic acid (0.16 g, 0.45 mmol) as a white solid.

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue triturated with Et2O

출처 및 근거

ORD 기록
ord-ff001e8bbfca4171a3d9c63355f09863
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552205B2

반응 노트

불러오는 중…