{1-[1-(4-Pyrrolidin-1-ylmethyl-pyridin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-carbamic acid benzyl ester → 1-Amino-cyclopropanecarboxylic acid [1-(4-pyrrolidin-1-ylmethyl-pyridin-2-yl)-cyclopropyl]-amide
반응식
C(OC(=O)[NH:10][C:11]1([C:14](=[O:31])[NH:15][C:16]2([C:19]3[CH:24]=[C:23]([CH2:25][N:26]4[CH2:30][CH2:29][CH2:28][CH2:27]4)[CH:22]=[CH:21][N:20]=3)[CH2:18][CH2:17]2)[CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[N:26]1([CH2:25][C:23]2[CH:22]=[CH:21][N:20]=[C:19]([C:16]3([NH:15][C:14]([C:11]4([NH2:10])[CH2:12][CH2:13]4)=[O:31])[CH2:17][CH2:18]3)[CH:24]=2)[CH2:30][CH2:29][CH2:28][CH2:27]1참가 물질
4
실험 절차
In a 100 mL one neck round bottom flask, {1-[1-(4-Pyrrolidin-1-ylmethyl-pyridin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-carbamic acid benzyl ester (67 mg, 0.154 mmol) was dissolved in MeOH (10 mL). 10 Wt. % Pd/C (15 mg) was then added. Nitrogen gas was bubbled through the suspension for 10 min. The reaction flask was evacuated and then filled with H2. This purging process was repeated twice and then the reaction was allowed to stir for 16 h under H2 (1 atm). The reaction mixture was filtered through celite. The filtrate was concentrated in vacuo to afford 39.3 mg of the title compound as a white solid.