반응식
IC1N(C)C=CN=1.BrC1C=CC=CN=1.C(N1CCC2C=C(N)C=CC=2CC1)C.[Cl:29][C:30]1[C:31]([NH:52][C:53]2[CH:58]=[CH:57][CH:56]=[CH:55][C:54]=2[C:59]2[CH:64]=[CH:63][CH:62]=[CH:61][N:60]=2)=[N:32][C:33]([NH:36][C:37]2[CH:51]=[CH:50][C:40]3[CH2:41][CH2:42][N:43]([CH2:46][CH2:47][O:48][CH3:49])[CH2:44][CH2:45][C:39]=3[CH:38]=2)=[N:34][CH:35]=1.COCCN1CCC2C=C(N)C=CC=2CC1>>[Cl:29][C:30]1[C:31]([NH:52][C:53]2[CH:58]=[CH:57][CH:56]=[CH:55][C:54]=2[C:59]2[CH:64]=[CH:63][CH:62]=[CH:61][N:60]=2)=[N:32][C:33]([NH:36][C:37]2[CH:51]=[CH:50][C:40]3[CH2:41][CH2:42][N:43]([CH2:46][CH2:47][O:48][CH3:49])[CH2:44][CH2:45][C:39]=3[CH:38]=2)=[N:34][CH:35]=1참가 물질
5
반응물 4
HCID 79732-Bromopyridine
HCID 3358352-Iodo-1-methyl-1H-imidazole
HCID 189434013-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine
HCID 1317309003-(2-Methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine 5-Chloro-N*2*-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-N*4*-(2-pyridin-2-yl-phenyl)-pyrimidine-2,4-diamine생성물 1
실험 절차
Example 224 was synthesized analogously to Example 216 replacing 2-iodo-1-methyl-1H-imidazole with 2-bromopyridine and 3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine with 3-(2-Methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine 5-Chloro-N*2*-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-N*4*-(2-pyridin-2-yl-phenyl)-pyrimidine-2,4-diamine was isolated as a foam. (m+H)=503.02. 1H NMR (400 MHz, MeOD, d4) δ 8.97 (d, 2H, J=4.94 Hz), 8.76 (m, 1H), 8.60 (d, 1H, J=7.82 Hz), 8.13 (s, 1H), 7.56 (s, 1H), 7.45 (m, 3H), 7.28 (m, 2H), 7.21 (d, 1H, J=8.13 Hz), 3.79 (m, 4H), 3.51 (m, 2H), 3.47 (s, 3H), 3.25 (m, 2H), 3.15 (m, 4H).
후처리
- customwas isolated as a foam
출처 및 근거
- ORD 기록
- ord-f3656d7b8d754300bbe8823dde9b3d9d
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08552186B2
연결된 노트
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