HCID 57522618, 화합물 → 5-Chloro-N2-[7-(2,2-difluoro-ethylamino)-2-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yl]-N4-(2-pyrazol-1-yl-phenyl)-pyrimidine-2,4-diamine

반응식

ClC1N=C(N[C@@H]2[C@@H]3C[C@@H](C=C3)[C@@H]2C(N)=O)C(Cl)=CN=1.Cl[C:21]1[N:26]=[C:25]([NH:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[N:34]2[CH:38]=[CH:37][CH:36]=[N:35]2)[C:24]([Cl:39])=[CH:23][N:22]=1.COC1C(N)=CC2CCC(N3CCOCC3)CCC=2C=1.[F:60][CH:61]([F:78])[CH2:62][NH:63][CH:64]1[CH2:70][CH2:69][C:68]2=[C:71]([NH2:77])[C:72]([O:75][CH3:76])=[CH:73][CH:74]=[C:67]2[CH2:66][CH2:65]1>>[Cl:39][C:24]1[C:25]([NH:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[N:34]2[CH:38]=[CH:37][CH:36]=[N:35]2)=[N:26][C:21]([NH:77][C:71]2[C:68]3[CH2:69][CH2:70][CH:64]([NH:63][CH2:62][CH:61]([F:78])[F:60])[CH2:65][CH2:66][C:67]=3[CH:74]=[CH:73][C:72]=2[O:75][CH3:76])=[N:22][CH:23]=1