돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1041303생성일: 2026년 10월 26일

2,4,5-Trichloropyrimidine → (2,5-Dichloro-pyrimidin-4-yl)-(2-fluoro-6-methoxy-phenyl)-amine

https://huagongshe.com/reaction/1041303

반응식

참여 물질

역할이름HCID투입량
반응물2,4,5-TrichloropyrimidineHCID 237259—
반응물2-Fluoro-6-methoxyanilineHCID 459253—
생성물(2,5-Dichloro-pyrimidin-4-yl)-(2-fluoro-6-methoxy-phenyl)-amineHCID 86633994—

반응 단계

(2,5-Dichloro-pyrimidin-4-yl)-(2-fluoro-6-methoxy-phenyl)-amine was prepared from 2,4,5-Trichloro-pyrimidine and 2-Fluoro-6-methoxyaniline in an analogous manner to Example 1230a. Title product was obtained as an off white solid (3.80 g, 62%). MP=133-135. LCMS 289.03 (M+H), HPLC purity=94%, 1H-NMR (DMSO-d6, 400 MHz) δ 9.24 (s, 1H), 8.35 (s, 1H), 7.39-7.35 (m, 1H), 7.00-6.91 (m, 2H), 3.80 (s, 3H).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08552186B2
출처 데이터셋uspto-grants-2013_10
ORD IDord-1248a766ab444830a330564e74354667
출처 메모uspto-grants-2013_10