Sodium periodate → Tert-butyl (1-(2-(7-formyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

HRID 1041965노트

반응식

HRID 1041965 반응식
I([O-])(=O)(=O)=O.[Na+].[OH:7][CH:8]([C:11]1[CH:16]=[CH:15][N:14]2[C:17]([C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[C:23]([N:30]5[CH2:35][CH2:34][CH:33]([CH2:36][NH:37][C:38](=[O:44])[O:39][C:40]([CH3:43])([CH3:42])[CH3:41])[CH2:32][CH2:31]5)[CH:24]=[CH:25][CH:26]=4)[N:21]=3)=[N:18][N:19]=[C:13]2[CH:12]=1)CO>C(Cl)Cl>[CH:8]([C:11]1[CH:16]=[CH:15][N:14]2[C:17]([C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[C:23]([N:30]5[CH2:31][CH2:32][CH:33]([CH2:36][NH:37][C:38](=[O:44])[O:39][C:40]([CH3:42])([CH3:41])[CH3:43])[CH2:34][CH2:35]5)[CH:24]=[CH:25][CH:26]=4)[N:21]=3)=[N:18][N:19]=[C:13]2[CH:12]=1)=[O:7]

참가 물질

4

반응물 2

HCID 23667635Sodium periodateHCID 86654349Tert-butyl (1-(2-(7-(1,2-dihydroxyethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

생성물 1

HCID 86654350Tert-butyl (1-(2-(7-formyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a slurry of silica gel (0.1 g) in DCM (3 mL) was added sodium periodate (0.13 mL, 0.087 mmol). The reaction was stirred for 10 minutes. tert-Butyl (1-(2-(7-(1,2-dihydroxyethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate (30 mg, 0.058 mmol) in DCM (2 mL) was then added to the slurry. The reaction was stirred for 30 minutes, then filtered and washed with DCM (20 mL). The organic layer was concentrated to give crude product.

후처리

  1. stirringThe reaction was stirred for 30 minutes
  2. filtrationfiltered
  3. washwashed with DCM (20 mL)
  4. concentrationThe organic layer was concentrated
  5. customto give crude product

출처 및 근거

ORD 기록
ord-f56aba911ee54afe88a3757b2b4dc2dd
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557809B2

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