2-Hydrazinyl-4-iodopyridine → Tert-butyl (1-(2-((2-(4-iodopyridin-2-yl)hydrazono)methyl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

HRID 1041969

반응식

HRID 1041969 반응식
[CH:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[C:6]([N:13]3[CH2:18][CH2:17][CH:16]([CH2:19][NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:15][CH2:14]3)[CH:7]=[CH:8][CH:9]=2)[N:4]=1)=O.[NH:28]([C:30]1[CH:35]=[C:34]([I:36])[CH:33]=[CH:32][N:31]=1)[NH2:29]>>[I:36][C:34]1[CH:33]=[CH:32][N:31]=[C:30]([NH:28][N:29]=[CH:1][C:3]2[CH:12]=[CH:11][C:10]3[C:5](=[C:6]([N:13]4[CH2:14][CH2:15][CH:16]([CH2:19][NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:26])[CH3:24])[CH2:17][CH2:18]4)[CH:7]=[CH:8][CH:9]=3)[N:4]=2)[CH:35]=1

참가 물질

3

반응물 2

HCID 534028972-Hydrazinyl-4-iodopyridineHCID 86654345Tert-butyl (1-(2-formylquinolin-8-yl)piperidin-4-yl)methylcarbamate

생성물 1

HCID 86654351Tert-butyl (1-(2-((2-(4-iodopyridin-2-yl)hydrazono)methyl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

실험 절차

Prepared as described in Example 1, steps D-E, using tert-butyl (1-(2-formylquinolin-8-yl)piperidin-4-yl)methylcarbamate in place of 8-(tert-butyldimethylsilyloxy)quinoline-2-carbaldehyde, and 2-hydrazinyl-4-iodopyridine in place of 2-Hydrazinyl-4-(2-methoxyethoxy)pyridine.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-da0987edf8d844ed93dab5fdd75e626c
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557809B2

연결된 노트

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