HCID 59609970, 화합물 → HCID 44180852, 화합물
반응식
[OH:1][C:2]1[C:7]([C:8](=[O:18])[CH2:9][C:10]([CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=O)=[CH:6][CH:5]=[CH:4][C:3]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>[Cu](Cl)Cl.C(O)C>[C:19]1([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]3[C:2]=2[O:1][C:10]([CH:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)=[CH:9][C:8]3=[O:18])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1참가 물질
4
반응 조건
- 온도
- 140 °C
실험 절차
A 5 mL microwave vial was charged with a magnetic stirring bar, crude 1-(2-hydroxybiphenyl-3-yl)-3-(tetrahydro-2H-pyran-4-yl)propane-1,3-dione (320 mg, 1 mmol), ethanol (3 mL), and copper (II) chloride (13 mg, 0.1 mmol). The reaction vial was sealed, the reaction mixture magnetically stirred and heated via microwave irradiation to 140° C. for 10 minutes. The resulting solution was concentrated in vacuo and purified by high-pressure liquid chromatography to give 8-phenyl-2-(tetrahydro-2H-pyran-4-yl)-4H-chromen-4-one (67).