2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one → HCID 178478242, 화합물

HRID 1042042

반응식

HRID 1042042 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[O:8][C:9]3[C:14]([C:15](=O)[CH:16]=2)=[CH:13][CH:12]=[CH:11][C:10]=3[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:3][CH2:2]1.COC(Cl)[Cl:27]>>[Cl-:27].[Cl:27][C:15]1[C:14]2[C:9](=[C:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:11]=[CH:12][CH:13]=2)[O+:8]=[C:7]([N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)[CH:16]=1

참가 물질

3

반응물 2

HCID 39732-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneHCID 21004Methane, dichloromethoxy-

생성물 1

HCID 178478242HCID 178478242, 화합물

반응 조건

온도
80 °C

실험 절차

A solution of 2-morpholino-8-phenyl-4H-chromen-4-one (LY294002) (1.50 g, 4.93 mmol) and dichloromethyl methyl ether (15 mL) was stirred and heated to 80° C. for 2 hours under argon. The mixture was cooled to room temperature, and then concentrated in vacuo to give 4-chloro-2-morpholino-8-phenylchromenylium chloride (78) (2.06 g, 5.73 mmol).

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-46b2983438f841b6a62cea41dd274a12
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557807B2

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