반응식
[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH:12](O)=O>>[CH3:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:5])[NH:6][CH:12]=[N:1]2)=[CH:7][CH:8]=1참가 물질
3
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 2-amino-4-methylbenzamide (20 g, 133 mmol) and formic acid (120 ml, 3129 mmol) was heated to 100° C. for 6 h. The reaction was cooled to RT and the volatiles were removed under reduced pressure. The residue was then washed carefully with aqueous saturated sodium bicarbonate and then with water. The tan solid was then dried in a vacuum oven at 45° C. overnight to give 7-methylquinazolin-4(3H)-one (18.00 g, 84% yield). MS (ESI, pos. ion) m/z: 161 [M+H]+
후처리
- temperatureThe reaction was cooled to RT
- customthe volatiles were removed under reduced pressure
- washThe residue was then washed carefully with aqueous saturated sodium bicarbonate
- customThe tan solid was then dried in a vacuum oven at 45° C. overnight
출처 및 근거
- ORD 기록
- ord-60582e02612445eba4e8741687084f5f
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08557830B2
연결된 노트
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