Triethylamine → HCID 178453336, 화합물

HRID 1042604노트

반응식

HRID 1042604 반응식
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[N:10]=[CH:9]1)=O)(C)(C)C.C(N(CC)CC)C>CO>[C:19]([O:18][C:16](=[O:17])[NH:15][CH2:14][CH2:13][C:11]1[N:10]=[CH:9][NH:8][CH:12]=1)([CH3:22])([CH3:20])[CH3:21]

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 819122tert-butyl 4-{2-[(tert-butoxycarbonyl)amino]ethyl}-1H-imidazole-1-carboxylate

생성물 1

HCID 178453336HCID 178453336, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 4-(2-tert-Butoxycarbonylamino-ethyl)-imidazole-1-carboxylic acid tert-butyl ester, were added 100 mL of methanol and 800 mL (5.73 mol) of triethylamine. The reaction mixture was allowed to stir at room temperature for four days and concentrated to oil. To the residue were added 40 mL of ether and 80 mL of hexane. This mixture was allowed to stand at room temperature resulting in precipitation of product, as a white solid, which were collected. The yield was 1.7 g (8.0 mmol, 40%) (LC/MS M+H 212.1).

후처리

  1. concentrationconcentrated to oil
  2. additionTo the residue were added 40 mL of ether and 80 mL of hexane
  3. customto stand at room temperature
  4. customresulting in precipitation of product, as a white solid, which
  5. customwere collected

출처 및 근거

ORD 기록
ord-ea7f02024f5c4e3e99dea81d3be5ad68
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557989B2

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