1,3-Propanediamine, N1,N1,N3-trimethyl- → HCID 16109013, 화합물

반응식

[Br:1][C:2]1[CH:7]=[CH:6][C:5](F)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[CH3:12][N:13]([CH3:19])[CH2:14][CH2:15][CH2:16][NH:17][CH3:18]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:17]([CH3:18])[CH2:16][CH2:15][CH2:14][N:13]([CH3:19])[CH3:12])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

참가 물질

반응물 2

HCID 783021,3-Propanediamine, N1,N1,N3-trimethyl-

HCID 27363284-Bromo-1-fluoro-2-nitrobenzene

생성물 1

HCID 16109013HCID 16109013, 화합물

실험 절차

To a round bottom flask at 0° C. was added 4-Bromo-1-fluoro-2-nitrobenzene (10 g, 45.46 mmol) and N,N,N′-Trimethyl-propane-1,3-diamine (6.99 ml, 47.73 mmol). The reaction was allowed to warm to RT and stirred for 16 h. The reaction was extracted into EtOAc, washed once with saturated aqueous NaHCO3, twice with water, and then dried over Mg2SO4. The organic layer was filtered and concentrated to yield the title compound as a bright orange solid.

후처리

extractionThe reaction was extracted into EtOAc
washwashed once with saturated aqueous NaHCO3, twice with water
dry with materialdried over Mg2SO4
filtrationThe organic layer was filtered
concentrationconcentrated

출처 및 근거

ORD 기록: ord-a9fccb10f35a42358339b8bd56120457
출처 데이터셋: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08557996B2

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