1,3-Dioxane-4,6-dione, 5-[[(6-methoxy-3-pyridinyl)amino]methylene]-2,2-dimethyl- → 6-Methoxy-1,5-naphthyridin-4-ol

HRID 1042776노트

반응식

HRID 1042776 반응식
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([NH:9][CH:10]=[C:11]2[C:16](=[O:17])OC(C)(C)OC2=O)=[CH:5][CH:4]=1>C1(OC2C=CC=CC=2)C=CC=CC=1.CCCCCC>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:6](=[CH:5][CH:4]=1)[NH:9][CH:10]=[CH:11][C:16]2=[O:17]

참가 물질

4

반응물 1

HCID 42557991,3-Dioxane-4,6-dione, 5-[[(6-methoxy-3-pyridinyl)amino]methylene]-2,2-dimethyl-

생성물 1

HCID 113788076-Methoxy-1,5-naphthyridin-4-ol

시약·촉매·용매 2

HCID 7583Diphenyl Ether용매HCID 8058Hexane용매

반응 조건

온도
250 °C

실험 절차

A suspension of 5-((6-methoxypyridin-3-ylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (51.3 g, 0.185 mol) in diphenylether (1275 mL) was heated to 250° C. under nitrogen atmosphere for 20 min. The reaction mixture was cooled to RT and diluted with hexane. The gummy solid was then triturated with hexane to obtain 6-methoxy-1,5-naphthyridin-4(1H)-one as a pale brown color solid.

후처리

  1. temperatureThe reaction mixture was cooled to RT
  2. customThe gummy solid was then triturated with hexane

출처 및 근거

ORD 기록
ord-405b923aa1cc4732abf67bfa1c661d57
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557816B2

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