참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(Oxan-4-yl)piperidin-4-amine dihydrochloride | HCID 45156751 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 3-Nitro-4-(1-(tetrahydro-2h-pyran-4-yl)piperidin-4-ylamino)benzenesulfonamide | HCID 67126384 | — |
반응 단계
A mixture of EXAMPLE 49B (22.12 g), water (43 mL), and triethylamine (43.6 mL) in 1,4-dioxane (300 mL) was stirred at room temperature until EXAMPLE 49B completely dissolved. The solution was then treated with 4-chloro-3-nitrobenzenesulfonamide (20.3 g), heated at 90° C. for 16 hours, cooled and concentrated. 10% Methanol in dichloromethane was added, and the solution was stirred vigorously at room temperature until a fine suspension existed and then the mixture was filtered.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08557983B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_10 |
|---|
| ORD ID | ord-ecb768994d8841958612b1ef64118a30 |
|---|
| 출처 메모 | uspto-grants-2013_10 |
|---|
