Triethylamine → HCID 178521573, 화합물

HRID 1043155노트

반응식

HRID 1043155 반응식
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([OH:8])[CH2:4][CH2:3]1.Br[CH2:10][CH2:11][O:12][CH2:13][CH2:14]Br.C(N(CC)CC)C>C(#N)C>[O:12]1[CH2:13][CH2:14][N:1]([C@H:2]2[CH2:7][CH2:6][C@H:5]([OH:8])[CH2:4][CH2:3]2)[CH2:10][CH2:11]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 21521Bis(2-bromoethyl) etherHCID 178511715HCID 178511715, 화합물

생성물 1

HCID 178521573HCID 178521573, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
60 °C

실험 절차

Trans-4-aminocyclohexanol (0.5 g), 1-bromo-2-(2-bromoethoxy)ethane (1.07 g) and triethylamine (2.42 mL) were dissolved in anhydrous acetonitrile (20 mL). The reaction mixture was heated at 60° C. overnight. The organic solvent was removed under vacuum. The residue was purified by flash column chromatography on silica gel eluting with 7-10% methanol in dichloromethane to give the title compound.

후처리

  1. customThe organic solvent was removed under vacuum
  2. customThe residue was purified by flash column chromatography on silica gel eluting with 7-10% methanol in dichloromethane

출처 및 근거

ORD 기록
ord-e0eb7b5a10034f47a4c289635afae941
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557983B2

반응 노트

불러오는 중…