Ethylene Oxide → HCID 68207020, 화합물

HRID 1043531노트

반응식

HRID 1043531 반응식
[F:1][C:2]([F:18])([F:17])[O:3][C:4]1[CH:16]=[CH:15][C:7]([O:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1.[CH2:19]1[O:21][CH2:20]1>ClCCl>[F:18][C:2]([F:1])([F:17])[O:3][C:4]1[CH:16]=[CH:15][C:7]([O:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:19][CH2:20][OH:21])[CH2:13][CH2:14]2)=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 6354Ethylene OxideHCID 161154394-[4-(Trifluoromethoxy)phenoxy]piperidine

생성물 1

HCID 68207020HCID 68207020, 화합물수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

4-(4-(trifluoromethoxy)phenoxy)piperidine (1.31 g, 5.0 mmol) was dissolved in dry dichloromethane (30 mL), cooled to 0° C. in ice salt-bath, added ethylene oxide (2.55 mL, 50 mmol), reacted for 3 h in ice salt-bath, stopped the reaction, the reaction was monitored by TLC, the system was spun dry after complete reaction to give 1.52 g title compound, yield was 100%.

후처리

  1. customreacted for 3 h in ice salt-bath
  2. customthe reaction
  3. customthe system was spun dry
  4. customafter complete reaction

출처 및 근거

ORD 기록
ord-f538d4d1da294f38a05bdb4acff51478
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563547B2

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