Ammonia → 5-Aminouracil

HRID 1043555

반응식

HRID 1043555 반응식
N.[N+:2]([C:5]1[C:6](=[O:12])[NH:7][C:8](=[O:11])[NH:9][CH:10]=1)([O-])=O>O>[NH2:2][C:5]1[C:6](=[O:12])[NH:7][C:8](=[O:11])[NH:9][CH:10]=1

참가 물질

4

반응물 2

HCID 222Ammonia2회HCID 691355-Nitrouracil

생성물 1

HCID 136115-Aminouracil

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
75 °C

실험 절차

Into a 5-L 4-necked round-bottom flask were placed water (2.871 L), ammonia (116.1 mL) and 5-nitropyrimidine-2,4(1H,3H)-dione (180 g, 1.15 mol, 1.00 equiv). This was followed by the addition of Na2S2O2 (860 g, 6.06 mol, 4.30 equiv) in several batches. The pH value of the solution was adjusted to 8 with ammonia (25%). The resulting solution was stirred for 3 h (hours) at 75° C. The reaction mixture was cooled to 15° C. with an ice/water bath. The solid was collected by filtration. This resulted in 118 g (81%) of 5-aminopyrimidine-2,4(1H,3H)-dione 1 as a yellow solid (see Scheme 1).

후처리

  1. customInto a 5-L 4-necked round-bottom flask were placed
  2. temperatureThe reaction mixture was cooled to 15° C. with an ice/water bath
  3. filtrationThe solid was collected by filtration
  4. customThis resulted in 118 g (81%) of 5-aminopyrimidine-2,4(1H,3H)-dione 1 as a yellow solid (see Scheme 1)

출처 및 근거

ORD 기록
ord-806d22519b394529a2a8b4188d7e8cb7
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563540B2

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