반응식
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]=[C:8]([Cl:19])[N:9]=[C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[C:11]=2[N:12]=1.[NH:20]1[CH2:23][CH:22]([N:24]2[CH2:29][CH2:28][NH:27][C:26](=[O:30])[CH2:25]2)[CH2:21]1>>[Cl:19][C:8]1[N:9]=[C:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:11]2[N:12]=[C:3]([CH2:2][N:20]3[CH2:21][CH:22]([N:24]4[CH2:29][CH2:28][NH:27][C:26](=[O:30])[CH2:25]4)[CH2:23]3)[CH:4]=[CH:5][C:6]=2[N:7]=1참가 물질
3
실험 절차
4-(6-(bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine 7 (0.201 g) was reacted with 4-(azetidin-3-yl)piperazin-2-one via General Procedure B to afford 0.18 g 4-(1-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)azetidin-3-yl)piperazin-2-one.
출처 및 근거
- ORD 기록
- ord-ecd275c52cb84cab9ad4d03c97824ebd
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08563540B2
연결된 노트
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