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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1043649생성일: 2026년 10월 26일

2-(Hydroxyethyl)benzimidazole → 2-(1-((2-(2-(2-hydroxyethyl)-1H-benzo[d]imidazol-1-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol

https://huagongshe.com/reaction/1043649

반응식

참여 물질

역할이름HCID투입량
반응물2-(Hydroxyethyl)benzimidazoleHCID 78570—
반응물2-(1-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-olHCID 58404970—
생성물2-(1-((2-(2-(2-hydroxyethyl)-1H-benzo[d]imidazol-1-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-olHCID 53377618—

반응 단계

2-(1-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol from Example 8 (0.15 g) was reacted with 2-(1H-benzo[d]imidazol-2-yl)ethanol via General Procedure D to produce 19 mg of 168 following reverse phase HPLC purification. MS (Q1) 532.3 (M)+

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08563540B2
출처 데이터셋uspto-grants-2013_10
ORD IDord-3a67ed27f0a54e51b8f7943c9ff90985
출처 메모uspto-grants-2013_10