2-(2-Dimethylaminoethoxy)-5-nitropyridine → 6-[2-(Dimethylamino)ethoxy]pyridin-3-amine

HRID 1043773노트

반응식

HRID 1043773 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][CH2:12][N:13]([CH3:15])[CH3:14])=[N:8][CH:9]=1)([O-])=O.[H][H]>CO.[Pd]>[CH3:14][N:13]([CH3:15])[CH2:12][CH2:11][O:10][C:7]1[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 529049082-(2-Dimethylaminoethoxy)-5-nitropyridineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 206914066-[2-(Dimethylamino)ethoxy]pyridin-3-amine수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-(5-Nitropyridin-2-yloxy)-N,N-dimethylethanamine (295 mg, 1.40 mmol) was dissolved in 5 mL of methanol and placed under a nitrogen atmosphere. A catalytic amount of 10% palladium on carbon was added and a hydrogen balloon was connected to the reaction flask. The flask was flushed five times with hydrogen and stirred at room temperature under hydrogen atmosphere for 16 hours. The solid was filtered and washed with methanol. The filtrate was evaporated under reduced pressure yielding 6-[2-(dimethylamino)ethoxy]pyridin-3-amine as a brown oil (250 mg, 99%). LC/MS (m/z): 182.1 (MH+), Rt 0.36 minutes.

후처리

  1. customThe flask was flushed five times with hydrogen
  2. filtrationThe solid was filtered
  3. washwashed with methanol
  4. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-a39d4ca8aa0044f593ddfd6df198905a
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563549B2

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