2-[(1-Methyl-4-piperidinyl)oxy]-5-nitropyridine → 6-[(1-methylpiperidin-4-yl)oxy]pyridin-3-amine

HRID 1043775노트

반응식

HRID 1043775 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][N:10]=2)[CH2:4][CH2:3]1.[H][H]>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([O:8][C:9]2[N:10]=[CH:11][C:12]([NH2:15])=[CH:13][CH:14]=2)[CH2:6][CH2:7]1

참가 물질

5

반응물 2

HCID 529048992-[(1-Methyl-4-piperidinyl)oxy]-5-nitropyridineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 283176056-[(1-methylpiperidin-4-yl)oxy]pyridin-3-amine수율 98%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-(1-Methylpiperidin-4-yloxy)-5-nitropyridine (100 mg, 0.42 mmol) was dissolved in 5 mL of methanol and placed under a nitrogen atmosphere. A catalytic amount of 10% palladium on carbon was added and a hydrogen balloon connected to the reaction flask. The flask was flushed five times with hydrogen and stirred at room temperature under hydrogen atmosphere. The solid was filtered and washed with methanol. The filtrate was evaporated under reduced pressure to yield 6-(1-methylpiperidin-4-yloxy)pyridin-3-amine as a brown solid (85 mg, 98%). LC/MS (m/z): 2082 (MH+), Rt 0.34 minutes.

후처리

  1. customThe flask was flushed five times with hydrogen
  2. filtrationThe solid was filtered
  3. washwashed with methanol
  4. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f20905eac33e4850a12cf399388b048b
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563549B2

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