3-Chloropropionyl chloride → 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

HRID 1043823

반응식

HRID 1043823 반응식
C([N:8]1[CH2:17][CH2:16][C:15]2[N:14]=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=[CH:11][C:10]=2[CH2:9]1)C1C=CC=CC=1.ClCCC(Cl)=O>ClCCl>[F:21][C:18]([F:19])([F:20])[C:13]1[CH:12]=[CH:11][C:10]2[CH2:9][NH:8][CH2:17][CH2:16][C:15]=2[N:14]=1

참가 물질

4

반응물 2

HCID 693643-Chloropropionyl chlorideHCID 577709166-Benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

생성물 1

HCID 534719842-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

To a solution of 5 (500 mg, 1.7 mmol) in dichoromethane (8 mL) was added compound 6, 3-chloro propionyl chloride (0.22 mL, 2.1 mmol) and the reaction mixture was stirred at 40° C. for 18 h. The reaction was then cooled to room temperature and concentrated. The resulting residue was dissolved in methanol (16 mL) and stirred at 40° C. for 3 h. The mixture was then cooled to room temperature and concentrated.

후처리

  1. temperatureThe reaction was then cooled to room temperature
  2. concentrationconcentrated
  3. dissolutionThe resulting residue was dissolved in methanol (16 mL)
  4. stirringstirred at 40° C. for 3 h
  5. temperatureThe mixture was then cooled to room temperature
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ea0d4bec166348a088b680e664e78c47
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563566B2

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