Dimethylformamide → 3-Bromo-6-methoxy-2,4-dimethylpyridine

HRID 1043889노트

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HRID 1043889 반응식
[Br:1][C:2]1[C:3]([CH3:10])=[N:4][C:5](Cl)=[CH:6][C:7]=1[CH3:8].CN([CH:14]=[O:15])C.C[O-].[Na+]>O>[Br:1][C:2]1[C:3]([CH3:10])=[N:4][C:5]([O:15][CH3:14])=[CH:6][C:7]=1[CH3:8]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 10942334Sodium MethoxideHCID 714643513-Bromo-6-chloro-2,4-dimethylpyridine

생성물 1

HCID 112413813-Bromo-6-methoxy-2,4-dimethylpyridine

시약·촉매·용매 1

HCID 962Water용매

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온도
60 °C

실험 절차

3-bromo-6-chloro-2,4-dimethylpyridine obtained in Preparation Example 21 (200 mg) was added to DMF (1 mL). Sodium methoxide (28% solution in methanol, 0.741 mL) was added to the solution, and the mixture was stirred at 60° C. for 15 hours. Water was added to the reaction mixture, followed by extraction with diethyl ether. The organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%) to give the title compound (172 mg).

후처리

  1. extractionfollowed by extraction with diethyl ether
  2. concentrationThe organic layer was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%)

출처 및 근거

ORD 기록
ord-9d9fa4fc783643cb9777faa0cab256b9
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563565B2

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